Loss of Perineuronal Net in ME7 Prion Disease
نویسندگان
چکیده
منابع مشابه
Loss of Perineuronal Net in ME7 Prion Disease.
Microglial activation and behavioral abnormalities occur before neuronal loss in experimental murine prion disease; the behavioral changes coincide with a reduction in synaptic plasticity. Because synaptic plasticity depends on an intact perineuronal net (PN), a specialized extracellular matrix that surrounds parvalbumin (PV)-positive GABAergic (gamma-aminobutyric acid [GABA]) inhibitory intern...
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Prion diseases are fatal, chronic neurodegenerative diseases of mammals, characterized by amyloid deposition, astrogliosis, microglial activation, tissue vacuolation and neuronal loss. In the ME7 model of prion disease in the C57BL/6 J mouse, we have shown previously that these animals display behavioural changes that indicate the onset of neuronal dysfunction. The current study examines the ne...
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ژورنال
عنوان ژورنال: Journal of Neuropathology & Experimental Neurology
سال: 2008
ISSN: 0022-3069,1554-6578
DOI: 10.1097/nen.0b013e3181654386